M46L (p.Met46Leu) variant of CYP2B6 (Cytochrome P450 2B6)
M46L (p.Met46Leu) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
M46L (p.Met46Leu) variant details
- p.Met46Leu
- 1000Genomes rs35303484
- ESP rs35303484
- ExAC rs35303484
- TOPMed rs35303484
- Missense
- Variant Prioritization Score for Impact Estimate 0.126
- REVEL 0.05
- MetaLR 0.00
- MetaSVM -0.90
- CADD 4.93
- PolyPhen-2 0.01
- SIFT 0.80
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available