L7F (p.Leu7Phe) variant of CYP2B6 (Cytochrome P450 2B6)
L7F (p.Leu7Phe) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
L7F (p.Leu7Phe) variant details
- p.Leu7Phe
- TOPMed rs1968915766
- gnomAD rs1968915766
- Missense
- Variant Prioritization Score for Impact Estimate 0.364
- REVEL 0.34
- MetaLR 0.32
- MetaSVM -0.78
- CADD 14.10
- PolyPhen-2 0.99
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available