L6H (p.Leu6His) variant of CYP2B6 (Cytochrome P450 2B6)
L6H (p.Leu6His) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L6H (p.Leu6His) variant details
- p.Leu6His
- TOPMed rs1305654573
- gnomAD rs1305654573
- Missense
- Variant Prioritization Score for Impact Estimate 0.445
- REVEL 0.38
- MetaLR 0.24
- MetaSVM -0.81
- CADD 22.30
- PolyPhen-2 0.57
- SIFT 0.10
- Most common in the Finnish in Finland (FIN) population (allele frequency 9.4e-05)
- Structural context available