L3I (p.Leu3Ile) variant of CYP2B6 (Cytochrome P450 2B6)
L3I (p.Leu3Ile) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
L3I (p.Leu3Ile) variant details
- p.Leu3Ile
- cosmic curated COSV60698
- gnomAD rs1347870921
- Missense
- Variant Prioritization Score for Impact Estimate 0.128
- REVEL 0.01
- MetaLR 0.14
- MetaSVM -1.00
- CADD 5.02
- PolyPhen-2 0.08
- SIFT 0.33
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available