L39P (p.Leu39Pro) variant of CYP2B6 (Cytochrome P450 2B6)
L39P (p.Leu39Pro) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, published literature, and structural context.
L39P (p.Leu39Pro) variant details
- p.Leu39Pro
- gnomAD 19-40991421-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.517
- REVEL 0.50
- MetaLR 0.44
- MetaSVM -0.09
- CADD 22.30
- PolyPhen-2 0.75
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available