L39F (p.Leu39Phe) variant of CYP2B6 (Cytochrome P450 2B6)
L39F (p.Leu39Phe) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
L39F (p.Leu39Phe) variant details
- p.Leu39Phe
- cosmic curated COSV10740
- ExAC rs756494044
- TOPMed rs756494044
- gnomAD rs756494044
- Missense
- Variant Prioritization Score for Impact Estimate 0.139
- REVEL 0.15
- MetaLR 0.07
- MetaSVM -1.09
- CADD 0.03
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available