L37M (p.Leu37Met) variant of CYP2B6 (Cytochrome P450 2B6)
L37M (p.Leu37Met) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
L37M (p.Leu37Met) variant details
- p.Leu37Met
- ExAC rs753039447
- TOPMed rs753039447
- gnomAD rs753039447
- Missense
- Variant Prioritization Score for Impact Estimate 0.471
- REVEL 0.45
- MetaLR 0.52
- MetaSVM -0.05
- CADD 22.00
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the East Asian population (allele frequency 0.00033)
- Structural context available