L19R (p.Leu19Arg) variant of CYP2B6 (Cytochrome P450 2B6)
L19R (p.Leu19Arg) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L19R (p.Leu19Arg) variant details
- p.Leu19Arg
- gnomAD rs1396279340
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.47
- MetaLR 0.26
- MetaSVM -0.82
- CADD 16.60
- PolyPhen-2 0.52
- SIFT 0.35
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available