L18F (p.Leu18Phe) variant of CYP2B6 (Cytochrome P450 2B6)
L18F (p.Leu18Phe) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
L18F (p.Leu18Phe) variant details
- p.Leu18Phe
- TOPMed rs1201606999
- gnomAD rs1201606999
- Missense
- Variant Prioritization Score for Impact Estimate 0.18
- REVEL 0.06
- MetaLR 0.15
- MetaSVM -0.99
- CADD 6.51
- PolyPhen-2 0.01
- SIFT 0.44
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available