L12F (p.Leu12Phe) variant of CYP2B6 (Cytochrome P450 2B6)
L12F (p.Leu12Phe) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
L12F (p.Leu12Phe) variant details
- p.Leu12Phe
- cosmic curated COSV60700
- ExAC rs758475406
- TOPMed rs758475406
- gnomAD rs758475406
- Missense
- Variant Prioritization Score for Impact Estimate 0.174
- REVEL 0.05
- MetaLR 0.17
- MetaSVM -0.99
- CADD 0.14
- PolyPhen-2 0.00
- SIFT 0.32
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available