K61T (p.Lys61Thr) variant of CYP2B6 (Cytochrome P450 2B6)
K61T (p.Lys61Thr) in CYP2B6 (Cytochrome P450 2B6) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
K61T (p.Lys61Thr) variant details
- p.Lys61Thr
- ExAC rs777256437
- TOPMed rs777256437
- gnomAD rs777256437
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.276
- REVEL 0.13
- MetaLR 0.38
- MetaSVM -0.65
- CADD 17.70
- PolyPhen-2 0.59
- SIFT 0.06
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available