F55L (p.Phe55Leu) variant of CYP2B6 (Cytochrome P450 2B6)
F55L (p.Phe55Leu) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
F55L (p.Phe55Leu) variant details
- p.Phe55Leu
- TOPMed rs1224263684
- gnomAD rs1224263684
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.14
- MetaLR 0.09
- MetaSVM -0.97
- CADD 5.31
- PolyPhen-2 0.09
- SIFT 0.72
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available