R77W (p.Arg77Trp) variant of CYP2A6 (Cytochrome P450 2A6)
R77W (p.Arg77Trp) in CYP2A6 (Cytochrome P450 2A6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
R77W (p.Arg77Trp) variant details
- p.Arg77Trp
- ExAC rs763613869
- TOPMed rs763613869
- gnomAD rs763613869
- Missense
- Variant Prioritization Score for Impact Estimate 0.196
- REVEL 0.08
- CADD 18.60
- PolyPhen-2 0.12
- SIFT 0.01
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available