P41S (p.Pro41Ser) variant of CYP2A6 (Cytochrome P450 2A6)
P41S (p.Pro41Ser) in CYP2A6 (Cytochrome P450 2A6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
P41S (p.Pro41Ser) variant details
- p.Pro41Ser
- TOPMed rs1417214526
- gnomAD rs1417214526
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.30
- CADD 23.40
- PolyPhen-2 0.98
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 4.9e-05)
- Structural context available