P37T (p.Pro37Thr) variant of CYP2A6 (Cytochrome P450 2A6)
P37T (p.Pro37Thr) in CYP2A6 (Cytochrome P450 2A6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
P37T (p.Pro37Thr) variant details
- p.Pro37Thr
- rs766052140
- ExAC rs766052140
- TOPMed rs766052140
- gnomAD rs766052140
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.427
- REVEL 0.20
- CADD 23.30
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 7.3e-05)
- Structural context available