L40W (p.Leu40Trp) variant of CYP2A6 (Cytochrome P450 2A6)
L40W (p.Leu40Trp) in CYP2A6 (Cytochrome P450 2A6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
L40W (p.Leu40Trp) variant details
- p.Leu40Trp
- ExAC rs772654177
- gnomAD rs772654177
- Missense
- Variant Prioritization Score for Impact Estimate 0.444
- REVEL 0.40
- CADD 22.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 9.6e-05)
- Structural context available