F111L (p.Phe111Leu) variant of CYP2A6 (Cytochrome P450 2A6)
F111L (p.Phe111Leu) in CYP2A6 (Cytochrome P450 2A6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
F111L (p.Phe111Leu) variant details
- p.Phe111Leu
- ExAC rs759590848
- gnomAD rs759590848
- Missense
- Variant Prioritization Score for Impact Estimate 0.225
- REVEL 0.19
- CADD 8.08
- PolyPhen-2 0.11
- SIFT 0.09
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available