V35A (p.Val35Ala) variant of CYP1A2 (Cytochrome P450 1A2)
V35A (p.Val35Ala) in CYP1A2 (Cytochrome P450 1A2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
V35A (p.Val35Ala) variant details
- p.Val35Ala
- gnomAD 15-74749842-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.15
- CADD 21.80
- PolyPhen-2 0.70
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available