V27M (p.Val27Met) variant of CYP1A2 (Cytochrome P450 1A2)
V27M (p.Val27Met) in CYP1A2 (Cytochrome P450 1A2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
V27M (p.Val27Met) variant details
- p.Val27Met
- ExAC rs759309532
- TOPMed rs759309532
- gnomAD rs759309532
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.11
- CADD 19.40
- PolyPhen-2 0.38
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 0.00033)
- Structural context available