P42S (p.Pro42Ser) variant of CYP1A2 (Cytochrome P450 1A2)
P42S (p.Pro42Ser) in CYP1A2 (Cytochrome P450 1A2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
P42S (p.Pro42Ser) variant details
- p.Pro42Ser
- ExAC rs756500317
- gnomAD rs756500317
- Missense
- Variant Prioritization Score for Impact Estimate 0.527
- REVEL 0.38
- CADD 23.80
- PolyPhen-2 0.98
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available