L3S (p.Leu3Ser) variant of CYP1A2 (Cytochrome P450 1A2)
L3S (p.Leu3Ser) in CYP1A2 (Cytochrome P450 1A2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
L3S (p.Leu3Ser) variant details
- p.Leu3Ser
- ExAC rs201871401
- TOPMed rs201871401
- gnomAD rs201871401
- Missense
- Variant Prioritization Score for Impact Estimate 0.189
- REVEL 0.18
- CADD 17.70
- PolyPhen-2 0.84
- SIFT 0.05
- Most common in the Ashkenazi Jewish population (allele frequency 0.00086)
- Structural context available