L37F (p.Leu37Phe) variant of CYP19A1 (Aromatase)
L37F (p.Leu37Phe) in CYP19A1 (Aromatase) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
L37F (p.Leu37Phe) variant details
- p.Leu37Phe
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- REVEL 0.11
- CADD 14.10
- PolyPhen-2 0.01
- SIFT 0.34
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available