L140F (p.Leu140Phe) variant of CYP19A1 (Aromatase)
L140F (p.Leu140Phe) in CYP19A1 (Aromatase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
L140F (p.Leu140Phe) variant details
- p.Leu140Phe
- ExAC rs780888050
- gnomAD rs780888050
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- REVEL 0.32
- CADD 22.90
- PolyPhen-2 0.79
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9.5e-07)
- Structural context available