F135L (p.Phe135Leu) variant of CYP17A1 (P05093)
F135L (p.Phe135Leu) in CYP17A1 (P05093) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
F135L (p.Phe135Leu) variant details
- p.Phe135Leu
- Ensembl rs2134084210
- Missense
- Variant Prioritization Score for Impact Estimate 0.485
- REVEL 0.51
- CADD 23.60
- PolyPhen-2 0.91
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available