E84V (p.Glu84Val) variant of CYP17A1 (P05093)
E84V (p.Glu84Val) in CYP17A1 (P05093) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
E84V (p.Glu84Val) variant details
- p.Glu84Val
- NCI-TCGA Cosmic COSV6400
- cosmic curated COSV64004
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.769
- REVEL 0.84
- CADD 29.20
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available