Y61C (p.Tyr61Cys) variant of CYP11B1 (P15538)
Y61C (p.Tyr61Cys) in CYP11B1 (P15538) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
Y61C (p.Tyr61Cys) variant details
- p.Tyr61Cys
- rs1410691484
- NCI-TCGA Cosmic COSV5282
- cosmic curated COSV52825
- TOPMed rs1410691484
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.28
- CADD 15.70
- PolyPhen-2 0.81
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available