G25S (p.Gly25Ser) variant of CYP11B1 (P15538)
G25S (p.Gly25Ser) in CYP11B1 (P15538) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G25S (p.Gly25Ser) variant details
- p.Gly25Ser
- rs771206231
- ClinGen CA4905727
- NCI-TCGA Cosmic COSV5282
- cosmic curated COSV52824
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.13
- CADD 13.80
- PolyPhen-2 0.05
- SIFT 0.09
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available