Y21S (p.Tyr21Ser) variant of CXCR4 (C-X-C chemokine receptor type 4)
Y21S (p.Tyr21Ser) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
Y21S (p.Tyr21Ser) variant details
- p.Tyr21Ser
- gnomAD 2-136115866-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.20
- MetaLR 0.16
- MetaSVM -0.87
- CADD 22.10
- PolyPhen-2 0.41
- SIFT 0.11
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available