Y21D (p.Tyr21Asp) variant of CXCR4 (C-X-C chemokine receptor type 4)
Y21D (p.Tyr21Asp) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
Y21D (p.Tyr21Asp) variant details
- p.Tyr21Asp
- gnomAD 2-136115867-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.08
- MetaLR 0.15
- MetaSVM -0.94
- CADD 22.70
- PolyPhen-2 0.01
- SIFT 0.16
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available