V59L (p.Val59Leu) variant of CXCR4 (C-X-C chemokine receptor type 4)
V59L (p.Val59Leu) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
V59L (p.Val59Leu) variant details
- p.Val59Leu
- gnomAD rs1314188521
- Missense
- Variant Prioritization Score for Impact Estimate 0.702
- REVEL 0.63
- AlphaMissense 0.92
- MetaLR 0.70
- MetaSVM 0.48
- CADD 25.60
- PolyPhen-2 0.99
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available