M63V (p.Met63Val) variant of CXCR4 (C-X-C chemokine receptor type 4)
M63V (p.Met63Val) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
M63V (p.Met63Val) variant details
- p.Met63Val
- gnomAD 2-136115741-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.13
- MetaLR 0.05
- MetaSVM -1.09
- CADD 21.40
- PolyPhen-2 0.01
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available