L61V (p.Leu61Val) variant of CXCR4 (C-X-C chemokine receptor type 4)
L61V (p.Leu61Val) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.
L61V (p.Leu61Val) variant details
- p.Leu61Val
- gnomAD 2-136115747-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.173
- REVEL 0.04
- MetaLR 0.05
- MetaSVM -1.09
- CADD 11.20
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available