K25R (p.Lys25Arg) variant of CXCR4 (C-X-C chemokine receptor type 4)
K25R (p.Lys25Arg) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
K25R (p.Lys25Arg) variant details
- p.Lys25Arg
- rs1387554691
- gnomAD rs1387554691
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.26
- REVEL 0.03
- MetaLR 0.12
- MetaSVM -0.96
- CADD 21.90
- PolyPhen-2 0.22
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available