I60V (p.Ile60Val) variant of CXCR4 (C-X-C chemokine receptor type 4)
I60V (p.Ile60Val) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
I60V (p.Ile60Val) variant details
- p.Ile60Val
- ExAC rs763059810
- gnomAD rs763059810
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.10
- MetaLR 0.15
- MetaSVM -0.95
- CADD 15.60
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available