G3R (p.Gly3Arg) variant of CXCR4 (C-X-C chemokine receptor type 4)
G3R (p.Gly3Arg) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
G3R (p.Gly3Arg) variant details
- p.Gly3Arg
- cosmic curated COSV54010
- TOPMed rs1684968738
- Missense
- Variant Prioritization Score for Impact Estimate 0.202
- REVEL 0.04
- AlphaMissense 0.24
- MetaLR 0.09
- MetaSVM -1.03
- CADD 15.60
- PolyPhen-2 0.41
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available