G17D (p.Gly17Asp) variant of CXCR4 (C-X-C chemokine receptor type 4)
G17D (p.Gly17Asp) in CXCR4 (C-X-C chemokine receptor type 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
G17D (p.Gly17Asp) variant details
- p.Gly17Asp
- rs770327175
- NCI-TCGA Cosmic COSV9960
- cosmic curated COSV99602
- ExAC rs770327175
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.08
- MetaLR 0.15
- MetaSVM -1.00
- CADD 19.00
- PolyPhen-2 0.01
- SIFT 0.17
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 0.0002)
- Structural context available