R8K (p.Arg8Lys) variant of CUX1 (Homeobox protein cut-like 1)
R8K (p.Arg8Lys) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R8K (p.Arg8Lys) variant details
- p.Arg8Lys
- TOPMed rs1401326458
- gnomAD rs1401326458
- Missense
- Variant Prioritization Score for Impact Estimate 0.203
- REVEL 0.06
- MetaLR 0.02
- MetaSVM -1.05
- CADD 18.50
- PolyPhen-2 0.00
- SIFT 0.84
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available
- CUX1 Homeobox domain domainome 1.0: score -0.516