R8G (p.Arg8Gly) variant of CUX1 (Homeobox protein cut-like 1)
R8G (p.Arg8Gly) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R8G (p.Arg8Gly) variant details
- p.Arg8Gly
- TOPMed rs1173103796
- gnomAD rs1173103796
- Missense
- Variant Prioritization Score for Impact Estimate 0.224
- REVEL 0.10
- MetaLR 0.04
- MetaSVM -1.10
- CADD 20.10
- PolyPhen-2 0.00
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available
- CUX1 Homeobox domain domainome 1.0: score -0.516