R50C (p.Arg50Cys) variant of CUX1 (Homeobox protein cut-like 1)
R50C (p.Arg50Cys) in CUX1 (Homeobox protein cut-like 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R50C (p.Arg50Cys) variant details
- p.Arg50Cys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.506
- REVEL 0.36
- MetaLR 0.14
- MetaSVM -0.97
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.165