R39W (p.Arg39Trp) variant of CUX1 (Homeobox protein cut-like 1)
R39W (p.Arg39Trp) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R39W (p.Arg39Trp) variant details
- p.Arg39Trp
- TOPMed rs1201682206
- gnomAD rs1201682206
- Missense
- Variant Prioritization Score for Impact Estimate 0.388
- REVEL 0.28
- MetaLR 0.25
- MetaSVM -0.61
- CADD 28.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.574