N22K (p.Asn22Lys) variant of CUX1 (Homeobox protein cut-like 1)
N22K (p.Asn22Lys) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, experimental measurements, and structural context.
N22K (p.Asn22Lys) variant details
- p.Asn22Lys
- cosmic curated COSV99035
- Missense
- Variant Prioritization Score for Impact Estimate 0.272
- REVEL 0.12
- MetaLR 0.11
- MetaSVM -1.09
- CADD 25.80
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.916