K10R (p.Lys10Arg) variant of CUX1 (Homeobox protein cut-like 1)
K10R (p.Lys10Arg) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K10R (p.Lys10Arg) variant details
- p.Lys10Arg
- TOPMed rs1394140833
- gnomAD rs1394140833
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- REVEL 0.05
- MetaLR 0.04
- MetaSVM -1.07
- CADD 23.10
- PolyPhen-2 0.02
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.863