I64T (p.Ile64Thr) variant of CUX1 (Homeobox protein cut-like 1)
I64T (p.Ile64Thr) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, experimental measurements, and structural context.
I64T (p.Ile64Thr) variant details
- p.Ile64Thr
- gnomAD rs1173048193
- Missense
- Variant Prioritization Score for Impact Estimate 0.521
- REVEL 0.47
- MetaLR 0.25
- MetaSVM -0.61
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.112