C3G (p.Cys3Gly) variant of CUX1 (Homeobox protein cut-like 1)
C3G (p.Cys3Gly) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
C3G (p.Cys3Gly) variant details
- p.Cys3Gly
- gnomAD 7-101817646-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.385
- REVEL 0.27
- MetaLR 0.17
- MetaSVM -0.73
- CADD 21.70
- PolyPhen-2 0.88
- SIFT 0.23
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.227
- Literature evidence available