A21V (p.Ala21Val) variant of CUX1 (Homeobox protein cut-like 1)
A21V (p.Ala21Val) in CUX1 (Homeobox protein cut-like 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A21V (p.Ala21Val) variant details
- p.Ala21Val
- cosmic curated COSV52904
- ExAC rs779702615
- TOPMed rs779702615
- gnomAD rs779702615
- Missense
- Variant Prioritization Score for Impact Estimate 0.401
- REVEL 0.24
- MetaLR 0.14
- MetaSVM -1.03
- CADD 26.60
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available
- CUX1 CUT domain domainome 1.0: score -0.469