R11W (p.Arg11Trp) variant of CUL3 (Cullin-3)
R11W (p.Arg11Trp) in CUL3 (Cullin-3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
R11W (p.Arg11Trp) variant details
- p.Arg11Trp
- 1000Genomes rs532085416
- ExAC rs532085416
- gnomAD rs532085416
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.12
- CADD 25.00
- PolyPhen-2 0.06
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available