K6N (p.Lys6Asn) variant of CUL3 (Cullin-3)
K6N (p.Lys6Asn) in CUL3 (Cullin-3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
K6N (p.Lys6Asn) variant details
- p.Lys6Asn
- NCI-TCGA Cosmic COSV5236
- cosmic curated COSV52363
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.238
- REVEL 0.04
- CADD 21.50
- PolyPhen-2 0.00
- SIFT 0.54
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available