F21L (p.Phe21Leu) variant of CUL3 (Cullin-3)
F21L (p.Phe21Leu) in CUL3 (Cullin-3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
F21L (p.Phe21Leu) variant details
- p.Phe21Leu
- NCI-TCGA Cosmic COSV1000
- cosmic curated COSV10002
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.11
- CADD 26.40
- PolyPhen-2 0.64
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available