V81L (p.Val81Leu) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
V81L (p.Val81Leu) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
V81L (p.Val81Leu) variant details
- p.Val81Leu
- TOPMed rs1431375309
- gnomAD rs1431375309
- Missense
- Variant Prioritization Score for Impact Estimate 0.121
- MetaLR 0.09
- MetaSVM -1.06
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 0.67
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available