T23P (p.Thr23Pro) variant of CTLA4 (Cytotoxic T-lymphocyte protein 4)
T23P (p.Thr23Pro) in CTLA4 (Cytotoxic T-lymphocyte protein 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
T23P (p.Thr23Pro) variant details
- p.Thr23Pro
- gnomAD 2-203868009-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- MetaLR 0.05
- MetaSVM -1.05
- CADD 6.98
- PolyPhen-2 0.37
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available